Endocrine Abstracts

The anti-inflammatory actions of glucocorticoids are mediated in part by inhibition of nuclear factor kappa B (NFkappaB) activation. Reports that NFkappaB activation within anterior pituitary folliculo-stellate (FS) cells provokes the release of interleukin-6 (IL-6) [1] which acts a paracrine mediator of ACTH release [2], raise the possibility that NFkappaB is a potential target for the negative feedback actions of glucocorticoids upon the hypothalamo-pitu...